Synthetic Approaches toward Monocyclic 3-Amino-β-lactams
نویسندگان
چکیده
منابع مشابه
Synthetic Approaches toward Monocyclic 3‐Amino‐β‐lactams
Due to the emerging resistance against classical β-lactam-based antibiotics, a growing number of bacterial infections has become harder to treat. This alarming tendency necessitates continued research on novel antibacterial agents. Many classes of β-lactam antibiotics are characterized by the presence of the 3-aminoazetidin-2-one core, which resembles the natural substrate of the target penicil...
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in this paper the synthesis of some new polyaromatic monocyclic β-lactams has been reported. these cycloadducts have been synthesized by the [2+2] ketene-imine cycloaddition reaction known as the staudinger reaction. all of the products have been fully characterized by ir, 1h-nmr, 13c-nmr, mass spectroscopy and elemental analyses. the x-ray crystal structure of a cis β-lactam has been also pres...
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synthesis of some new monocyclic β-lactams containing a quaternary carbon center via a [2+2]cycloaddition reaction is described. the reaction of achiral diphenyl ketene with chiral aldimines derivedfrom chiral 2, 3, 4, 6-tetra-o-acetyl-β-d-galactopyranosylamine, 2, 3, 4, 6-tetra-o-acetyl-β-dglucopyranosylamine and different benzaldehydes resulted in the formation of β-lactams as singlediastereo...
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Rhomboids are relatively recently discovered intramembrane serine proteases that are conserved throughout evolution. They have a wide range of biological functions, and there is also much speculation about their potential medical relevance. Although rhomboids are weakly inhibited by some broad-spectrum serine protease inhibitors, no potent and specific inhibitors have been identified for these ...
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ژورنال
عنوان ژورنال: ChemistryOpen
سال: 2017
ISSN: 2191-1363
DOI: 10.1002/open.201700051